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Evaluating the Accuracy of Multiple Blood Tests to Diagnose Sepsis in Adult Burn Patients

NCT07126574 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 165

Last updated 2025-08-17

No results posted yet for this study

Summary

This prospective diagnostic accuracy study evaluates the performance of presepsin and C-reactive protein (CRP) as early biomarkers for suspected sepsis in adult burn patients. From January 2021 to December 2022, 370 patients with ≥20% total body surface area burns admitted to the Burn Intensive Care Unit at Hallym University Hangang Sacred Heart Hospital were screened; 221 met inclusion criteria. At each clinical suspicion of sepsis (≥2 SIRS criteria), venous blood was drawn for simultaneous measurement of presepsin (via chemiluminescent immunoassay) and CRP (via immunoturbidimetric assay). Diagnostic accuracy will be quantified by sensitivity, specificity, positive/negative predictive values, and area under the ROC curve. The goal is to determine whether presepsin outperforms CRP for early sepsis detection in severe burn patients.

Conditions

  • Sepsis - to Reduce Mortality in the Intensive Care Unit
  • Burns Involving 20% or More of Body Surface

Sponsors & Collaborators

  • Dohern Kym

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-08-15
Primary Completion
2026-10-31
Completion
2026-10-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07126574 on ClinicalTrials.gov