Posterior Circulation Clot Burden Score (Pc-CBS) Predicts Clinical Outcome After Acute Ischemic Stroke Related to Posterior Circulation Occlusions : An Externally Validated Radiological Score

Summary

Posterior circulation strokes (PCS) represent \~30% of all ischemic strokes, but existing prognostic tools are limited, especially for non-basilar artery occlusions. Accurate early outcome prediction may aid treatment decisions and clinical trial design. We developed and externally validated the Posterior Circulation Clot Burden Score (PC-CBS), a radiological tool to predict 3-month functional outcome in acute ischemic stroke due to posterior circulation occlusion.

Conditions

• Acute Ischemic Stroke
• Posterior Circulation Brain Infarction
• Arterial Occlusion Disease

Interventions

DIAGNOSTIC_TEST

Assessment of cervico-cerebral arterial occlusion pattern

Assessment of cervico-cerebral arterial occlusion pattern for the development of a radiological score

Sponsors & Collaborators

• Insel Gruppe AG, University Hospital Bern

  collaborator OTHER

• Hospital de Egas Moniz

  collaborator OTHER

• University Hospital Heidelberg

  collaborator OTHER

• IRCCS Istituto delle Scienze Neurologiche di Bologna

  collaborator OTHER

• The University of Texas Health Science Center, Houston

  collaborator OTHER

• Azienda Ospedaliero-Universitaria di Modena

  collaborator OTHER

• Hospital Vall d'Hebron

  collaborator OTHER

• Boston University

  collaborator OTHER

• Università degli Studi di Brescia

  collaborator OTHER

• Medical University of Graz

  collaborator OTHER

• Hôpital Rothschild

  collaborator OTHER

• Medical University of Vienna

  collaborator OTHER

• Hebrew University of Jerusalem

  collaborator OTHER

• Michigan State University

  collaborator OTHER

• Medical University Innsbruck

  collaborator OTHER

• Ludwig-Maximilians - University of Munich

  collaborator OTHER

• Ospedale Policlinico San Martino

  collaborator OTHER

• EOC Lugano CH

  collaborator UNKNOWN

• University Hospital, Basel, Switzerland

  collaborator OTHER

• Aristotle University Of Thessaloniki

  collaborator OTHER

• Technische Universität Dresden

  collaborator OTHER

• Centre Hospitalier Universitaire Vaudois

  lead OTHER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2003-02-01

Primary Completion

2023-03-31

Completion

2025-08-08