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Extended Tricyle Project Indonesia for Extended-spectrum Beta-lactamase Positive Klebsiella Pneumoniae and Escherichia Coli

NCT07106944 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2025-08-06

No results posted yet for this study

Summary

In 2019, Indonesia's first WHO Tricycle Project revealed alarming rates of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli across various sectors. The study found ESBL-producing E. coli in 40% of pregnant women, 57.7% of E. coli-induced bloodstream infections, 67.1% of broiler chicken, and 12.8% of total E. coli in water samples. In the first National Action Plan on Antimicrobial Resistance from Indonesia, the reduction of ESBL was identified as a clear goal. In E-Trike, Tricycle will be repeated, using the same methodology, to determine if a reduction has been achieved. Additionally, ESBL-positive Klebsiella pneumoniae will be included, as important pathogen for humans.

Conditions

  • Carriage of ESBL-positive Escherichia Coli
  • Carriage of ESBL-positive Klebsiella Pneumoniae

Interventions

OTHER

Community pregnant women: rectal and throat swab

Community pregnant women: rectal and throat swab

Sponsors & Collaborators

  • Dr. Sulianti Saroso Hospital, Jakarta

    collaborator UNKNOWN

  • Universitas Indonesia, Cipto Mangunkusumo National General Hospital

    collaborator UNKNOWN

  • RSUP Persahabatan Hospital, Jakarta, Indonesia

    collaborator UNKNOWN

  • National Institute for Public Health and the Environment (RIVM)

    collaborator OTHER_GOV

  • Utrecht University

    collaborator OTHER

  • Erasmus Medical Center

    lead OTHER

Eligibility

Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-08-11
Primary Completion
2026-03-30
Completion
2026-04-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07106944 on ClinicalTrials.gov