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Effect of Antibiotics on Urinary Microbiome

NCT04230746 · Status: WITHDRAWN · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL

Last updated 2021-11-03

No results posted yet for this study

Summary

Planning to study urine microbiota at baseline and after administration of bactrim antibiotics in healthy volunteers. Will intermittently collect voided urine specimens for 16 s DNA analysis over a period of 6 months after 2 weeks of bactrim or placebo.

Conditions

  • Microtia
  • UTI
  • Bacteriuria
  • Antibiotic Resistant Infection
  • Antibiotics Causing Adverse Effects in Therapeutic Use

Interventions

DRUG

Bactrim DS 800Mg-160Mg Tablet

To study effect on urinary microbiome

DRUG

Placebo oral tablet

To study effect on urinary microbiome

Sponsors & Collaborators

Principal Investigators

  • Andrew J Cohen, MD · Johns Hopkins University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-31
Primary Completion
2025-02-28
Completion
2026-02-28
FDA Drug
Yes

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04230746 on ClinicalTrials.gov