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Neonatal Acquisition of ESBL-PE in a Low-income Country - NeoLIC

NCT04836208 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 600

Last updated 2022-10-07

No results posted yet for this study

Summary

Enterobacteriaceae, more specifically Escherichia coli and Klebsiella pneumoniae, are the bacteria most often responsible for neonatal infections in low-income countries. Infections caused by multidrug-resistant Enterobacteriaceae: Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E), are more often associated with an unfavorable outcome of the infection.

Enterobacteriaceae colonize the digestive tract which is the first step in developing a potential infection. Very few studies have been carried out at the community level. Colonization of the mother with ESBL-E is generally considered to be a major route of acquisition. The carrying of ESBL-E by other family members and other potential sources of transmission (food, objects and surfaces in contact with the newborn) have never been documented.

In addition, with a view to offering an intervention adapted to the local context, the local cultural determinants which govern the interactions of the newborn with his environment are important to understand.

Conditions

  • Enterobacteriaceae Infections

Sponsors & Collaborators

  • Institut Pasteur de Madagascar

    collaborator OTHER

  • Centre hospitalier de référence du District de Moramanga

    collaborator UNKNOWN

  • Institut Pasteur

    lead INDUSTRY

Principal Investigators

  • Bich-Tram Huynh · Institut Pasteur

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-04-30
Primary Completion
2023-05-31
Completion
2023-05-31

Countries

  • Madagascar

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04836208 on ClinicalTrials.gov