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The Nonirritating Concentrations of Midazolam, Ketamine, and Ondansetron

NCT07103720 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 21

Last updated 2026-04-01

No results posted yet for this study

Summary

Perioperative anaphylaxis is a potentially life-threatening drug allergic reaction that can occur during anesthetic procedures. The purpose of this research is to determine the maximal nonirritating skin testing concentrations of midazolam, ketamine and ondansetron. These drugs are FDA approved and commonly used before, during and after surgical procedures.

Conditions

  • Allergy

Interventions

DIAGNOSTIC_TEST

Skin Testing

Participants will undergo skin prick testing and intradermal test injections at 5 increasing concentrations of midazolam, ketamine and/or ondansetron during one single study visit.

Sponsors & Collaborators

  • Arizona Biomedical Research Commission (ABRC)

    collaborator OTHER

  • Mayo Clinic

    lead OTHER

Principal Investigators

  • Alexei Gonzalez Estrada, MD · Mayo Clinic

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-11-05
Primary Completion
2026-03-10
Completion
2026-03-10
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07103720 on ClinicalTrials.gov