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Sustained Auricular Nerve Stimulation for PVC Suppression

NCT07093034 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2025-10-16

No results posted yet for this study

Summary

Non-invasive vagus nerve stimulation has been clinically tested for the treatment cardiac arrhythmias. However, prior studies have shown mixed results-possibly in part due to inadequate stimulation duration. Therefore, we have designed an investigator-initiated early feasibility study to evaluate safety, tolerability, and compliance with prolonged, nocturnal auricular nerve stimulation using the Parasym device.

Conditions

  • Premature Ventricular Complexes
  • PVC - Premature Ventricular Contraction
  • Auricular Vagus Nerve Stimulation

Interventions

DEVICE

Extended nocturnal use of auricular vagus nerve stimulator device

Patients will wear the ParasymTM device with an ear clip on the tragus that provides stimulation at sub-detection threshold.

Sponsors & Collaborators

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-01
Primary Completion
2026-03-01
Completion
2026-05-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07093034 on ClinicalTrials.gov