Investigation of the Relationship Between Periodontitis and Alzheimer's Disease in Terms of Blood Parameters

Summary

The aim of this study was to analyse the possible relationship between periodontal inflammation and Alzheimer's disease and to investigate the role of blood parameters in this relationship.

Conditions

• Periodontal Disease
• Periodontitis
• Periodontal Inflammation
• Biomarkers / Blood
• Blood Cell Count
• Alzheimer Disease

Interventions

DIAGNOSTIC_TEST

Complete Blood Count Test

Complete blood count test provides data on total white blood cell count, neutrophil count, neutrophil percentage, lymphocyte count, lymphocyte percentage, monocyte count, monocyte percentage, eosinophil count, eosinophil percentage, basophil count, basophil percentage, platelet count, platelet distribution width (PDW), mean platelet volume (MPV), plateletcrit (PCT), erythrocyte count, hemoglobin, hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and red blood cell distribution width (RDW). In addition, neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-leukocyte ratio (PLR), Pan-Immune-Inflammation Value (PIV), Systemic Immune-Inflammation Index (SII), Hemoglobin-to-Red Cell Distribution Width Ratio (HRR) values are also formulated from these parameters.

DIAGNOSTIC_TEST

Periodontal examinations

With periodontal evaluation, plaque percentage, probing pocket depth, percentage of bleeding on probing, clinical attachment level, number of teeth, periodontal inflammatory surface area (PISA) parameters are recorded.

DIAGNOSTIC_TEST

Clinical Dementia Rating scale

Stage I: mild Alzheimer's disease, Stage II: moderate Alzheimer's disease, Stage III: severe Alzheimer's disease

DIAGNOSTIC_TEST

Standardized Mini-Mental Test

Cognitive status is assessed with the Standardized Mini-Mental Test.

Sponsors & Collaborators

• Uskudar University

  lead OTHER

Principal Investigators

• OZLEM GELISIN · Dr. Sadi Konuk Training and Research Hospital

• AHMET AYDOGDU · Istanbul Galata University

• SADIYE GUNPINAR · Bezmialem Vakif University

• ZEYNEP AKGUL · Abant Izzet Baysal University

• KUBRA KARADURAN · Uskudar University

Eligibility

Min Age

50 Years

Max Age

90 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-08-05

Primary Completion

2025-10-03

Completion

2025-11-03

Countries

• Turkey (Türkiye)

Study Locations