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Upfront Ultrasound for Preoperative Localization in Primary Hyperparathyroidism

NCT07068867 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 99

Last updated 2026-01-14

No results posted yet for this study

Summary

Primary hyperparathyroidism is caused by overactive parathyroid glands, leading to elevated calcium levels in the blood. The standard preoperative imaging includes both a radiation-based imaging modality and conventional ultrasound. However, ultrasound alone is a faster, safer, and more patient-friendly alternative. This study evaluates an upfront ultrasound approach, where patients undergo ultrasound first, and only those with certain findings proceed directly to surgery without additional imaging. Patients with uncertain findings proceed to additional imaging. The study is designed as a prospective cohort with a non-inferiority analysis, aiming to confirm whether upfront ultrasound can achieve an acceptable diagnostic sensitivity. If successful, this approach could reduce patient burden, minimize radiation exposure, and optimize healthcare resources

Conditions

  • Primary Hyperparathyroidism

Sponsors & Collaborators

  • Odense University Hospital

    lead OTHER

Principal Investigators

  • Sanne H Michaelsen, MD · Odense Universitetshospital

  • Viveque Egsgaard, MD, PhD · Odense Universitetshospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-09-01
Primary Completion
2025-09-18
Completion
2025-09-18

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07068867 on ClinicalTrials.gov