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Optimization and Individualization of Diagnostic Scintigraphy Protocol and Minimally Invasive Radio-guided Parathyroid Surgery

NCT04344886 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2022-12-07

No results posted yet for this study

Summary

The radio-guided technique offers both help with in-vivo identification and ex-vivo confirmation of parathyroid adenoma. In-vivo accuracy is most important but its results are not satisfactory. The aim of this study was to evaluate if there is a beneficial effect of individualized timing of surgery using preoperative multi-phase 99mTc-MIBI single-photon emission computed tomography (SPECT)/CT on in-vivo characteristics of minimally invasive radio-guided parathyroidectomy.

Conditions

  • Primary Hyperparathyroidism
  • Thyroid Disease
  • Parathyroid Diseases
  • Parathyroid Adenoma

Interventions

PROCEDURE

Conventional (dual-phase) SPECT/CT

Conventional (dual-phase) SPECT/CT (after 10 and 150 minutes)

PROCEDURE

Multi-phase SPECT/CT

Multi-phase SPECT/CT (after 10, 90, 150, 210 minutes)

PROCEDURE

Conventional minimally-invasive radio-guided parathyroidectomy

Conventional minimally invasive radio-guided parathyroidectomy in a time span of 2-3 hours from radionuclide administration

PROCEDURE

Individualised minimally-invasive radio-guided parathyroidectomy

Individualized minimally-invasive radio-guided parathyroidectomy performed in a recommended time span based on standardized uptake value calculation.

Sponsors & Collaborators

  • University Hospital Ostrava

    lead OTHER

Principal Investigators

  • Vladimír Dedek, MD,PhD · University Hospital Ostrava

  • Martin Formánek, MD,PhD · University Hospital Ostrava

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-05-01
Primary Completion
2020-11-30
Completion
2020-12-31

Countries

  • Czechia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04344886 on ClinicalTrials.gov