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IOPTH Usefulness for Predicting Successful Surgery in Secondary Hyperparathyroidism

NCT04484116 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2020-07-23

No results posted yet for this study

Summary

Secondary hyperparathyroidism (SHPT) is a multisystemic syndrome that affects calcium and bone homeostasis in patients with chronic kidney disease (CKD). Despite medical treatment, 1-2% of patients require parathyroidectomy anually. The use of an intraoperative paratohormone protocol (IOPTH) to predict cure still in debate, due to the lack of standardized protocols, the use of different assays and uneven PTH clearance. The aim of this study was to determine the diagnostic accuracy of an IOPTH in patients with SHPT for predicting successful surgery after parathyroidectomy.

Conditions

  • Secondary Hyperparathyroidism

Interventions

DIAGNOSTIC_TEST

Intraoperative Paratohormone

Three IOPTH determinations were withdrawn: at anesthetic induction (PTH0), 15 minutes (PTH15), and 30 minutes (PTH30) after completion gland resection. Another sample was taken 24 hours after the procedure (PTH24), values \<150pg/mL defined a successful surgery and patients were assigned to the successful or unsuccessful group. IOPTH drop was analyzed to predict successful surgery with drops of 70% and 90% at 15 and 30 minutes.

Sponsors & Collaborators

  • Hospital General Ajusco Medio

    lead OTHER

Principal Investigators

  • Karla V Chavez-Tostado, MD · SEDESA

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-07-01
Primary Completion
2019-11-30
Completion
2019-11-30

Countries

  • Mexico

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04484116 on ClinicalTrials.gov