HCMR Re-Imaging Study

Summary

This study aims to learn what might predict heart problems (like sudden death from a fast heart rhythm or heart failure) in people with a genetic condition called hypertrophic cardiomyopathy (HCM). HCM causes the heart muscle to become thick, which can make the heart stiff and harder to work properly. It can also affect the heart's electrical system.

This study is looking to enroll patients that were previously part of a research project called "HCMR - Novel Predictors of Outcome in Hypertrophic Cardiomyopathy." The results of that study are still being reviewed, but they might show that people who had a substance called Gadolinium (MRI contrast or dye) collected in their heart muscle may have a higher risk for heart problems, including sudden cardiac death. This is called "late gadolinium enhancement" (LGE). This study is aiming to do follow-up imaging on those patients to better understand how LGE affects people with HCM.

Conditions

• Hypertrophic Cardiomyopathy (HCM)

Interventions

OTHER

None - observational study

None - observational study

Sponsors & Collaborators

• Brigham and Women's Hospital

  collaborator OTHER

• Mayo Clinic

  collaborator OTHER

• Tufts Medical Center

  collaborator OTHER

• Northwestern University

  collaborator OTHER

• University of Michigan

  collaborator OTHER

• The Cleveland Clinic

  collaborator OTHER

• University Hospital Birmingham NHS Foundation Trust

  collaborator OTHER

• Glenfield Hospital, Leicester

  collaborator OTHER

• London Chest Hospital

  collaborator UNKNOWN

• Cytokinetics

  collaborator INDUSTRY

• Toronto General Hospital

  collaborator OTHER

• Christopher Kramer

  lead OTHER

Principal Investigators

• Christopher Kramer, MD · University of Virginia

• Stefan Neubauer, MD · University of Oxford

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-03-30

Primary Completion

2027-03-31

Completion

2027-07-31

Countries

• United States
• United Kingdom

Study Locations