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Low-Flow Anesthesia and Perioperative Atelectasis in Laparoscopic Bariatric Surgery

NCT07041567 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-05-20

No results posted yet for this study

Summary

The goal of this clinical trial is to learn whether low-flow anesthesia reduces perioperative atelectasis compared to normal-flow anesthesia in adults undergoing laparoscopic bariatric surgery. The main questions it aims to answer are:

Does low-flow anesthesia result in a smaller increase in lung ultrasound score from baseline to postoperative hour 1? Does low-flow anesthesia result in better preservation of pulmonary function at postoperative hour 48?

Researchers will compare low-flow anesthesia (fresh gas flow 0.5 L/min) to normal-flow anesthesia (fresh gas flow 2 L/min) to see if low-flow anesthesia reduces the extent of perioperative atelectasis as measured by lung ultrasound.

Participants will:

Be randomly assigned to receive either low-flow or normal-flow inhalational anesthesia with sevoflurane during surgery Undergo lung ultrasound assessments before surgery and at postoperative hours 1 and 24 Undergo spirometric testing one day before surgery and at postoperative hour 48

Conditions

  • Atelectasis
  • Pulmonary Complications
  • Ultrasonography
  • Bariatric Surgery
  • Low Flow Anesthesia

Interventions

DRUG

Sevoflurane with normal-flow anesthesia

Sevoflurane is delivered via inhalation with a fresh gas flow of 2 L/min throughout surgery. Vaporizer is set to 2.5%.

DRUG

Sevoflurane with low-flow anesthesia

Sevoflurane is delivered via inhalation. Anesthesia is initiated at FGF 4 L/min with vaporizer at 6% for rapid equilibration. Once end-tidal sevoflurane reaches 1.0 MAC, FGF is reduced to 0.5 L/min and titrated to maintain 1.0 MAC.

Sponsors & Collaborators

  • Istanbul University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-15
Primary Completion
2026-04-01
Completion
2026-04-15

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07041567 on ClinicalTrials.gov