The Effect of Anesthetic Methods on Gastrointestinal Motility

Summary

The goal of this randomized controlled single blinded study is to compare the effect of the type of anesthesia on gastrointestinal motility in patients scheduled for laparoscopic sleeve gastrectomy. The main question it aims to answer is how do inhalation anesthesia and total intravenous anesthesia effect the gastrointestinal peristalsis during anastomosis.

Participants will be American Society of Anesthesiology (ASA) physical status II and III, between 18- 60 ages.

Researchers will compare inhalation anesthesia where desflurane is used with total intravenous anesthesia to see if the gastrointestinal motility differs between the groups.

Conditions

• Anesthesia
• Total Intravenous Anesthesia

Interventions

DRUG

Desflurane

In inhalation group, desflurane will be used for general anesthesia maintenance under the screening with Patient State Index (PSI) between a score of 25-50. Remifentanil infusion is used with desflurane with a dose of 0.05-2 mcg/ kg/ min according to PSI . Fresh gas flow is used 2 L/ min with a mixture of 50%- 50% oxygen and medical air in both groups.

DRUG

Remifentanil infusion

Remifentanil infusion will be used with a dose of 0.05-2 mcg/ kg/ min under the screening with Patient State Index (PSI) between a score of 25-50 in both groups.

OTHER

Fresh gas

Fresh gas flow will be used 2 L/ min with a mixture of 50%- 50% oxygen and medical air in both groups.

DRUG

Propofol infusion

Propofol infusion will be used for general anesthesia maintenance with a dose of under the screening of Patient State Index (PSI) between a score of 25-50 in group tiva.

Sponsors & Collaborators

• Bozyaka Training and Research Hospital

  lead OTHER

Principal Investigators

• Halide H Şahinkaya, MD · Izmir Bozyaka Education and Research Hospital

• Ahmet M Öztürk, MD · Izmir Bozyaka Education and Research Hospital

• Çağlar Ayar, MD · Izmir Bozyaka Education and Research Hospital

• Hüseyin Özkarakaş, MD · Izmir Bozyaka Education and Research Hospital

• Bülent Çalık, Ass. Prof · Izmir Bozyaka Education and Research Hospital

• Zeki T Tekgül, Ass. Prof. · Izmir Bozyaka Education and Research Hospital

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-08-15

Primary Completion

2023-10-15

Completion

2023-12-31

Countries

• Turkey (Türkiye)

Study Locations