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AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

NCT07038343 · Status: RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 480

Last updated 2026-05-13

No results posted yet for this study

Summary

This study, the first clinical trial of AVZO-1418, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and antitumor activity of AVZO-1418 when administered intravenously as a monotherapy and potentially in combination therapy to patients with locally advanced or metastatic epithelial solid tumors.

Conditions

  • Solid Tumor Cancer
  • Locally Advanced
  • Metastatic Solid Tumors
  • Lung Cancers
  • Epithelial Tumor
  • Biliary Tract Cancer (BTC)
  • Urothelial Cancer
  • Nasopharyngeal Cancers

Interventions

DRUG

AVZO-1418

Specific dose in protocol specified schedule

DRUG

Combination Agent 1

Per label based on combination agent used

DRUG

Combination Agent 2

Per label based on combination agent used

Sponsors & Collaborators

  • Avenzo Therapeutics, Inc.

    lead INDUSTRY

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-06-04
Primary Completion
2030-06-30
Completion
2030-12-31
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07038343 on ClinicalTrials.gov