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Comparative Evaluation of Hyaluronic Acid Spray and Low-Level Laser Therapy on Wound Healing Following Gingivectomy: A Randomized, Noninferiority Trial

NCT07034625 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 64

Last updated 2025-12-05

No results posted yet for this study

Summary

Gingival enlargement is a common condition caused by increased cell numbers, leading to connective tissue expansion. It can hinder plaque control and cause aesthetic and functional problems, often requiring surgical intervention. Gingivectomy is the primary procedure for treating gingival enlargement, ensuring periodontal health. Postoperative low-level laser therapy (LLLT) may reduce inflammation, relieve pain, and accelerate tissue regeneration. Similarly, hyaluronic acid (HA) stimulates cell proliferation, migration, and differentiation, promoting wound healing. This study aimed to compare the effects of LLLT and HA spray on early wound healing after gingivectomy.

Conditions

  • Gingival Enlargement

Interventions

OTHER

Low Level Laser Therapy

940 nm wavelength diode laser was applied to the wound area on the surgery day, 3rd, 5th and 7th days postoperatively. The power of the laser was set to 3W, power density 1.07 W/cm2, probe spot size 2.8 cm2, application mode continuous wave, application distance 1mm and application type stable.

OTHER

Gengigel Spray

Patients were given a high molecular weight hyaluronic acid spray and instructions for use were explained. Accordingly, the patients applied the spray to the wound area twice a day for the first 7 days.

Sponsors & Collaborators

  • Akdeniz University

    lead OTHER

Principal Investigators

  • Nezahat Arzu Kayar, PhD, DDS · Akdeniz University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-06-01
Primary Completion
2025-06-01
Completion
2025-07-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07034625 on ClinicalTrials.gov