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Adjunctive 0.8% Hyaluronic Acid Gel in Open-Flap Surgery for Thin Gingival Phenotype in Patients With Periodontitis

NCT07130266 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 37

Last updated 2025-08-27

No results posted yet for this study

Summary

The aim of this study is to evaluate the clinical effectiveness of 0.8% hyaluronic acid (HA) gel as an adjunct to open flap debridement (OFD) in periodontitis patients with a thin gingival phenotype.

The primary research question is:

Does the adjunctive use of 0.8% HA gel reduce gingival recession and improve clinical parameters? To answer this, researchers will compare the adjunctive use of 0.8% HA gel to physiological saline in combination with OFD, assessing their effects on clinical outcomes and gingival recession in patients with a thin gingival phenotype.

Participants will:

* Receive 0.8% HA gel application during OFD surgery and a second application at 4 weeks postoperatively.
* Attend follow-up visits at 1, 3, and 6 months after surgery for clinical assessments and measurements.

Conditions

  • Hyaluronic Acid
  • Open Flap Debridement
  • Periodontitis
  • Gingival Phenotype
  • Gingival Recession

Interventions

PROCEDURE

Procedure/Surgery: Hyaluronic acid gel application

After root surface cleaning and infected cement removal, 0.8% HA gel was applied to the root surface, bone, and inner surface of the flap and left for 2 minutes.

PROCEDURE

giving an impression of the application

In the control group, instead of HA gel, the area was irrigated with physiological saline solution.

Sponsors & Collaborators

  • Bezmialem Vakif University

    lead OTHER

Principal Investigators

  • Sadiye Gunpinar, Assoc. Prof. · Bezmialem Vakif University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-05-09
Primary Completion
2023-06-22
Completion
2023-06-22

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07130266 on ClinicalTrials.gov