Reset: Enhancing Weight Loss in a Digital Intervention

Summary

The goal of the Reset trial is to learn about the optimal combination of dietary behavior strategies in a fully digital weight loss intervention. The intervention is designed for adults with overweight or obesity. The investigators will examine the impact on weight loss of four dietary strategies: 1) limiting Red Zone Foods (i.e., foods that are high in calories and low in nutrition), 2) limiting eating windows, 3) increasing protein intake, and 4) increasing fiber intake. Each of these strategies will include goal setting, daily self-monitoring, and tailored feedback.

The investigators will recruit 208 participants. Broadly, adults with overweight or obesity who live in the U.S. will be eligible. The weight loss intervention will last 12 weeks. All participants will be asked to track their body weight daily and complete weekly behavioral lessons and action plans to promote healthy eating and physical activity. All study tasks will occur remotely. Assessment of body weight and survey measures will occur at the beginning of the trial ("baseline"), and at 1 month and 3 months.

The Multiphase Optimization Strategy (MOST) framework will be used to identify which combination of the dietary behavior strategies results in the greatest weight loss. In total, there will be 16 treatment conditions.

Conditions

• Obesity
• Overweight
• Weight Loss
• Health Behavior
• Lifestyle Intervention

Interventions

BEHAVIORAL

Core Behavioral Weight Loss Intervention

All participants receive a 12-week core behavioral weight loss intervention consisting of the following: daily self-monitoring of weight; weekly behavioral lessons and action plans to promote healthy eating and physical activity; and tailored feedback. The intervention will be delivered remotely via email and/or text message.

BEHAVIORAL

Limit Red Zone Foods

Participants randomized to receive this component are given a goal to limit their Red Zone Foods (i.e., foods high in calories and low in nutrition) and are instructed to self-monitor them daily.

BEHAVIORAL

Limit Eating Window

Participants randomized to receive this component are given a goal to limit their eating windows (i.e., follow time-restricted eating) and are instructed to self-monitor them daily.

BEHAVIORAL

Increase Protein

Participants randomized to receive this component are given a goal to increase their protein intake and are instructed to self-monitor it daily.

BEHAVIORAL

Increase Fiber Intake

Participants randomized to receive this component are given a goal to increase their fiber intake and are instructed to self-monitor it daily.

Sponsors & Collaborators

• Stanford Nutrition and Obesity Research Center

  collaborator UNKNOWN

• Stanford University

  lead OTHER

Principal Investigators

• Michele L Patel, PhD · Stanford University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

FACTORIAL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-04-30

Primary Completion

2026-08-31

Completion

2026-08-31

Countries

• United States

Study Locations