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Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1

NCT07030725 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2025-06-25

No results posted yet for this study

Summary

Brown adipose tissue becomes activated during cold conditions to increase thermogenesis (i.e., energy expenditure). Topical menthol application increases resting energy expenditure but it is unclear whether brown adipose tissue activation contributes to this rise in the energy expenditure. The overall goal with this project is to determine whether topical menthol application stimulates brown adipose tissue.

Conditions

  • Regulation of Energy Expenditure

Interventions

DRUG

Menthol Gel

Menthol (5% L-menthol) will be applied to the anterior thorax.

DRUG

Sham

Sham gel applied to the anterior thorax.

BEHAVIORAL

Time control

No gel applied to anterior thorax.

Sponsors & Collaborators

  • Indiana University

    lead OTHER

Principal Investigators

  • Blair D Johnson, PhD · Indiana University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-03-27
Primary Completion
2026-03-31
Completion
2026-09-30
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07030725 on ClinicalTrials.gov