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The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes

NCT07022951 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1200000

Last updated 2026-04-08

No results posted yet for this study

Summary

Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful. This study intends to characterize perioperative fasting practices and their potential effects on clinical outcomes through possible effects on patient well-being (anxiety, hunger, thirst), physiology (hypovolemia, hypotension), perioperative aspiration, etc. The research team hypothesized that in addition to known adverse effects on patients' well-being, prolonged preoperative fasting adversely affects circulating blood volume-related (hypotension, decreased urine output etc.) and glucose metabolism-related (e.g., hypo/hyperglycemia) perioperative physiology. The investigators will also test for an association between the duration of preoperative fasting and the risk of perioperative pulmonary aspiration.

Additional knowledge on the potential adverse effects of preoperative fasting will inform preoperative fasting policies and research interventions that are relevant to hundreds of millions of patients subjected to preoperative/preprocedural fasting worldwide each year.

Conditions

  • Anesthesia
  • Sedation
  • Monitored Anesthesia Care
  • Procedure
  • Surgery, Day
  • Surgery
  • Surgery Scheduled
  • Fasting Before Operation
  • Aspiration; Gastric Contents, Anesthesia

Interventions

OTHER

Preoperative fasting

This cohort study assesses the duration of preoperative fasting and its clinical effects

Sponsors & Collaborators

  • Anesthesia Patient Safety Foundation (APSF)

    collaborator UNKNOWN

  • Massachusetts General Hospital

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-01-01
Primary Completion
2028-12-31
Completion
2030-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07022951 on ClinicalTrials.gov