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INCIDENCE, PREVALENCE AND OVERALL RISK OF ESOPHAGEAL CANCER IN ACHALASIA: A PROPENSITY-MATCHED POPULATION-BASED STUDY FROM A LARGE MULTICENTER DATABASE

NCT07022886 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 47000

Last updated 2025-07-30

No results posted yet for this study

Summary

Esophageal Achalasia has been investigated as a potential risk factor for esophageal cancer (EC). Longstanding disease, repeated treatment, age and male sex seem the most relevant risk factors, but no clear effect size estimation from large sample cohorts has been provided so far. The aim of the investigators is to estimate EC risk in large sample-size population, and to provide sub-analyses per cancer type and treatment impact on EC risk.

Conditions

  • Achalasia Cardia
  • Esophageal Cancer (EsC)

Interventions

PROCEDURE

achalasia treatments

esophageal achalasia treatments

Sponsors & Collaborators

  • TriNetX, LLC

    collaborator UNKNOWN

  • Vita-Salute San Raffaele University

    collaborator UNKNOWN

  • IRCCS San Raffaele

    lead OTHER

Principal Investigators

  • Albert Jan Bredenoord, MD, PhD, Prof · Department of Gastroenterology, Amsterdam UMC Location AMC, Amsterdam, The Netherlands

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-06-03
Primary Completion
2025-06-03
Completion
2025-09-07

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07022886 on ClinicalTrials.gov