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Nodal Status in Adenocarcinoma of the Esophagus an Cardia

NCT01635595 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 194

Last updated 2012-07-25

No results posted yet for this study

Summary

Adenocarcinoma of the distal esophagus and cardia are grouped among the thoracic tumors according to the TNM 7th ed., however controversy is pending on the unique or dual pathogenesis (GERD or gastric-like cancerogenesis). It has been shown that biological patterns differ according to the presence (+) or absence (-) of Barrett's epithelium (BIM) and gastric intestinal metaplasia (GIM) in the fundus and antrum. Lymphatic metastatic spreading may differ according to the type of tumor. The investigators retrospectively investigated the pathways of lymphatic spreading in 194 consecutive patients who received radical surgery for adenocarcinoma of the esophagus and cardia with or without BIM and GIM.

Conditions

  • Adenocarcinoma of the Esophagus
  • Adenocarcinoma of the Gastric Cardia

Interventions

PROCEDURE

Subtotal esophagectomy and gastric pull up

Subtotal esophagectomy and gastric pull up and radical thoracic (2,3,4R,7,8,9)and abdominal (15,16,17,18,19,20) lymphadenectomy

PROCEDURE

Subtotal esophagectomy at the azygos vein, total gastrectomy

Subtotal esophagectomy at the azygos vein, total gastrectomy and esophagojejunostomy and radical thoracic (2,3,4R,7,8,9) abdominal (15,16,17,18,19,20) lymphadenectomy.

Sponsors & Collaborators

  • University of Bologna

    lead OTHER

Principal Investigators

  • Sandro Mattioli, Prof. · University of Bologna

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-01-31
Completion
2011-12-31

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01635595 on ClinicalTrials.gov