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Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children

NCT07008092 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2025-06-06

No results posted yet for this study

Summary

Diagnosing acute appendicitis in children remains a clinical challenge, with delayed or incorrect diagnosis potentially leading to serious complications or unnecessary surgery. Prostaglandin E urinary metabolites (PGE-M) have been found elevated in various inflammatory conditions, but their diagnostic value in pediatric appendicitis is not well established. This study aims to assess the potential of PGE-M as a biomarker for acute appendicitis in children.

The study will be conducted over 12 months and will include 100 children aged 5 to 17 years presenting with acute abdominal pain. In addition to routine laboratory tests, urinary PGE-M levels will be analyzed. The study involves minimal risk to participants

Conditions

  • Acute Appendicitis
  • Acute Appendicitis With Rupture
  • Abdominal Pain (AP)

Interventions

DIAGNOSTIC_TEST

Blood specimen collection

Blood specimen collection for analysis of C-reactive protein, white blood cell count and neutrophile count.

DIAGNOSTIC_TEST

Urine collection

Urine sample collection for analysis of creatinine and prostaglandin E urinary metabolites

Sponsors & Collaborators

  • KBC Split

    lead OTHER

Eligibility

Min Age
5 Years
Max Age
17 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-06-02
Primary Completion
2026-05-01
Completion
2026-05-01

Countries

  • Croatia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07008092 on ClinicalTrials.gov