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Plasma Sodium: a Predictor of Perforation in Acute Appendicitis. (The NAP-study)

NCT04806789 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 451

Last updated 2024-11-27

No results posted yet for this study

Summary

This clinical prospective diagnostic accuracy study assesses plasma sodium concentration using blood gas analysis at the emergency department in children, age 1-15 years, with suspected acute appendicitis. The overall assumption is that using plasma sodium as a biomarker, a cut-off value of \<136 mmol/L will differentiate perforated from non-perforated acute appendicitis. In addition, traditionally used clinical diagnostic variables as well as radiology used in the diagnosis of acute appendicitis will also be obtained. Histopathology will be used to define if the appendix is perforated or not.

Conditions

  • Acute Appendicitis
  • Children, Only

Sponsors & Collaborators

  • Odense University Hospital

    collaborator OTHER

  • Charite University, Berlin, Germany

    collaborator OTHER

  • Red Cross War Memorial Childrens Hospital

    collaborator OTHER

  • Oslo University Hospital

    collaborator OTHER

  • Urban Fläring

    lead OTHER

Principal Investigators

  • Urban Fläring, Ass Prof · Karolinska Institutet

Eligibility

Min Age
1 Year
Max Age
15 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-01
Primary Completion
2024-11-25
Completion
2024-11-25

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04806789 on ClinicalTrials.gov