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Geometrical Influences on Atherosclerosis and Blood Flow

NCT07002697 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2025-06-03

No results posted yet for this study

Summary

The study investigates the use of advanced imaging techniques and computational methods to identify high-risk plaques in coronary arteries. These plaques are significant because they have the potential to cause acute coronary syndrome (ACS), a condition that includes heart attacks and unstable angina. The research focuses on integrating Coronary Computed Tomography (CCT) with Computational Fluid Dynamics (CFD) to provide detailed insights into plaque characteristics and their hemodynamic environment.

The study's primary aim is to enhance the early detection and characterization of high-risk coronary plaques that could lead to ACS. By combining CCT, a non-invasive imaging technique, with CFD, which stimulates blood flow dynamics, the study seeks to: Identify High-Risk Plaques, Apply CFD to analyze the blood flow around these plaques, Improve Prediction of ACS, Inform Clinical Decision-Making.

Computational fluid dynamics (CFD) analysis of CCT data can also provide a non-invasive hemodynamic assessment to identify high-risk plaques destined to cause acute coronary syndrome. Patients with adverse plaque characteristics like positive remodeling or low-attenuation plaque have a greater risk of future coronary events.

Conditions

  • Atherosclerosis and Blood Flow in Coronary Artery

Sponsors & Collaborators

  • National Institute of Cardiovascular Diseases, Bangladesh

    collaborator OTHER

  • Bangladesh University of Engineering and Technology

    lead OTHER

Principal Investigators

  • Muhammad Tarik Arafat, PhD · Department of Biomedical Engineering, Bangladesh University of Engineering and Technology (BUET), Dhaka - 1205

  • Dr. M G Azam, MBBS, MD, FSCAI · NICVD, Dhaka

Eligibility

Min Age
40 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-08-10
Primary Completion
2025-10-11
Completion
2026-04-11

Countries

  • Bangladesh

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07002697 on ClinicalTrials.gov