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Precision Sedation in Intensive Care

NCT06991777 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2025-05-28

No results posted yet for this study

Summary

Being critically ill and in need of mechanical ventilation is painful and distressing, and patients rarely have the capacity to communicate to express their needs. Doctors and nurses caring for critically ill patients in need of mechanical ventilation are constantly trying to balance patient comfort vs. patient safety. On one hand health care personnel (HCP) want to avoid unnecessary pain and suffering, on the other hand HCP want our patients to be able to communicate and avoid the complications associated with prolonged mechanical ventilation and Intensive Care Unit (ICU) stays. Our current tools for titrating sedation are subjective and variable, leading to large variations in sedation strategy between providers and frequent oversedation to "err on the side of caution".

This project is a grassroot initiative where physicians and nurses across various ICUs at Oslo University Hospital are highly motivated to research an alternative strategy for sedation in our units. The investigators believe a more precise approach to sedation that uses neurophysiologic and respiratory targets to guide medication dosing will significantly improve our overall quality of care. By avoiding oversedation, the investigators hope to help our patients wean off mechanical ventilation quicker, reduce their risk of delirium and cognitive deficit, resulting in fewer complications and shorter ICU stays. More precise sedation not only has the potential to improve outcomes for individual patients, but it can also improve ICU capacity and reduce the costs associated with prolonged ICU stays.

Conditions

  • Critical Illness

Interventions

DEVICE

Precision sedation in intensive care using neurophysiologic and respiratory targets.

Sedation titration using EEG and ventilator parameters

Sponsors & Collaborators

  • Oslo University Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-12-01
Primary Completion
2025-12-31
Completion
2026-05-31
FDA Device
Yes

Countries

  • Norway

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06991777 on ClinicalTrials.gov