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Investigating Multigene Methylation Dynamics in Treatment Response Surveillance for Intestinal Carcinoma

NCT06979882 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2025-05-20

No results posted yet for this study

Summary

The primary objective is to determine whether pretreatment-to-posttreatment changes in circulating multigene methylation levels correlate with objective response rates (ORR) assessed by contrast-enhanced CT/MRI and levels of serum tumor markers. Secondary endpoints include: (a) time-dependent association between methylation fluctuation patterns and progression-free survival (PFS), (b) comparative diagnostic accuracy of methylation indices versus conventional biomarkers, and (c) feasibility of using methylation thresholds to guide adaptive therapy modification.

Conditions

  • Intestinal Cancer

Interventions

OTHER

Multi-gene methylation testing

Undergo multi-gene methylation testing in blood during follow-up

OTHER

Multi-gene methylation testing

Undergo multi-gene methylation testing in blood during follow-up

OTHER

Multi-gene methylation testing

Undergo multi-gene methylation testing in blood during follow-up

Sponsors & Collaborators

  • Xijing Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-05-25
Primary Completion
2030-03-01
Completion
2030-03-01

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06979882 on ClinicalTrials.gov