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Bone and Body Composition Adaptations to Physical Training

NCT06972862 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 206

Last updated 2025-05-15

No results posted yet for this study

Summary

The goal of this clinical trial is to evaluate how different exercise programs alter bone density, structure, and strength in adults. It will also collect data on hormones, factors released from skeletal muscle, and body composition.

The main questions it aims to answer are:

* Do exercise programs that are frequent with high-impact loading will cause greater improvements in bone health?
* What changes in hormones, factors released from skeletal muscle, and body composition contribute to bone adaptations?

Researchers will compare different exercise groups to see if the type of exercise influences bone adaptation compared to a recreationally active control group.

Participants are asked to:

* complete questionnaires, 5 blood draws across the study (3 at rest, 2 after strenuous exercise), dual energy x-ray absorptiometry (DXA) scans (to assess bone mineral density and body composition), high resolution tibial scans to assess bone structure and geometry, and physical performance testing.
* attend up to 7 testing visits.
* (for those randomized to the exercise training intervention) participate in exercise training sessions for 6 months.

Conditions

  • Exercise
  • Healthy

Interventions

OTHER

Osteogenic Index Optimized Exercise Training Program

The OI- Optimized Training is 6 months of planned, non-linear periodized training on a leg press machine called the PPM (Athletic Republic, Salt Lake City, UT) with a maintenance program during the semester breaks, as necessary.

Sponsors & Collaborators

  • U.S. Army Medical Research and Development Command

    collaborator FED

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • Kristen J Koltun, PhD · University of Pittsburgh

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-08-29
Primary Completion
2025-04-27
Completion
2025-04-27

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06972862 on ClinicalTrials.gov