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Effects of Aerobic Versus Resistance Training on Bone Metabolism in Stage 3-4 Chronic Kidney Disease

NCT07133256 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2025-08-21

No results posted yet for this study

Summary

This randomized controlled trial investigates the comparative effects of aerobic versus resistance training on bone mineral density (BMD) and bone metabolism markers in patients with stage 3 or 4 chronic kidney disease (CKD). The primary aim is to evaluate the impact of two distinct exercise modalities on serum osteoprotegerin (OPG), receptor activator of nuclear factor kappa-B ligand (RANKL), and the OPG/RANKL ratio, as well as densitometric changes at key skeletal sites.

Conditions

  • Osteopenia
  • Bone Metabolism Disorders
  • Chronic Kidney Disease (Stage 3-4)
  • Mineral and Bone Disorder (CKD-MBD)

Interventions

BEHAVIORAL

Resistance Exercise

Structured machine-based resistance exercise protocol performed under supervision, targeting osteogenic loading to improve bone mineral density and alter bone metabolism markers in CKD stage 3-4 patients.

BEHAVIORAL

Aerobic Training

Participants in this arm performed supervised aerobic exercise (treadmill walking) three times per week for six months. Each session included: 5-minute warm-up 30-minute treadmill walking at 60%-80% of age-predicted maximum heart rate (HRmax = 220 - age) 10-minute cool-down Exercise sessions were supervised by trained exercise professionals and tailored to maintain target heart rate zones.

Sponsors & Collaborators

  • Sinai University

    lead OTHER

Principal Investigators

  • Dr. Shehab Abd E-Kader, Professor · 1Department of Physical Therapy, Faculty of Medical Rehabilitation Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-01-01
Primary Completion
2025-07-01
Completion
2025-07-25

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07133256 on ClinicalTrials.gov