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Physiological Dead Space and Intensive Care Mortality in Mechanically Ventilated Patients

NCT06963944 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2025-05-09

No results posted yet for this study

Summary

This study investigates the relationship between physiological dead space and clinical outcomes, specifically mortality and discharge status, in adult patients receiving invasive mechanical ventilation in the intensive care unit (ICU). Physiological dead space refers to ventilated but non-perfused regions of the lungs and can be quantified using the Enghoff-modified Bohr equation based on capnographic and arterial CO₂ measurements.

While volumetric capnography is a valuable tool in anesthesiology and perioperative care, its use in ICU settings remains limited. By continuously monitoring physiological dead space at the bedside, this study aims to provide real-time insight into ventilation-perfusion mismatch and assess its prognostic significance in critically ill patients.

Conditions

  • Invasive Mechanical Ventilation
  • Ventilation-Perfusion Mismatch
  • ICU Mortality
  • Critical Illness
  • End Tidal CO2

Sponsors & Collaborators

  • Karadeniz Technical University

    lead OTHER

Principal Investigators

  • Mehtap Pehlivanlar Kucuk, MD, Assoc. Prof. · Karadeniz Technical University, Faculty of Medicine

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-01
Primary Completion
2025-04-19
Completion
2025-04-19

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06963944 on ClinicalTrials.gov