Laparoscopic Versus Robot-assisted Left-sided Pancreatectomy for Benign and Pre-malignant Lesions (DIPLOMA-3)

Summary

The DIPLOMA-3 trial is an international, multicenter, patient-blinded randomized controlled trial comparing laparoscopic and robot-assisted left-sided pancreatectomy. Patients with an indication for elective left-sided pancreatecomy for benign or premalignant lesions in the body or tail of the pancreas and considered eligible will be randomized between laparoscopic and robot-assisted resection.

Conditions

• Pancreatectomy
• Distal Pancreatectomy (DP)
• Pancreatic Neoplasms
• Pancreatic Adenoma
• Pancreatic Cyst
• Pancreatic Cystadenoma
• Surgery
• Minimally Invasive Surgical Technique
• Minimally Invasive Distal Pancreatectomy
• Minimally Invasive Surgery

Interventions

PROCEDURE

Laparoscopic minimally invasive left-sided pancreatecomy

Laparoscopic minimally invasive left-sided pancreatecomy

PROCEDURE

Robot-assisted minimally invasive left-sided pancreatecomy

Robot-assisted minimally invasive left-sided pancreatecomy

Sponsors & Collaborators

• Leiden University Medical Center

  collaborator OTHER

• Catharina Ziekenhuis Eindhoven

  collaborator OTHER

• Erasmus Medical Center

  collaborator OTHER

• Medisch Spectrum Twente

  collaborator OTHER

• Maastricht University Medical Center

  collaborator OTHER

• University Medical Center Groningen

  collaborator OTHER

• Onze Lieve Vrouwe Gasthuis

  collaborator OTHER

• Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

  lead OTHER

Principal Investigators

• Prof. Mohammad Abu Hilal, MD PhD · University of Jordan

• Prof. Marc Besselink, MD, PhD · Amsterdam UMC

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-06-01

Primary Completion

2027-06-01

Completion

2028-06-01

Countries

• Netherlands

Study Locations