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How Bleeding Affects Delirium in Older Patients With Hip Fractures: The IMPROVE-HIP Study

NCT06938789 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 198

Last updated 2026-05-22

No results posted yet for this study

Summary

The goal of this clinical trial is to investigate whether early detection of bleeding and prompt blood transfusions can help prevent delirium in patients aged 75 and older who are admitted to the hospital with hip fractures. The main question the trial aims to answer is:

Do patients aged 75 and older with hip fractures benefit from earlier treatment of anemia (low blood count) to reduce the risk of delirium?

Researchers will compare early diagnosis and treatment of bleeding with standard care to determine if it helps lower the risk of developing delirium.

Participants will:

Undergo blood tests, have their vital signs monitored, and be screened for delirium three times a day for the first 48 hours after surgery.

Receive blood transfusions promptly if their hemoglobin levels fall below a specified threshold.

Attend a follow-up visit at 30 days to assess cognitive function and overall quality of life.

Attend another follow-up at 90 days to evaluate hospital readmissions and survival.

Conditions

  • Bleeding
  • Hip Fracture
  • Delirium - Postoperative

Interventions

OTHER

Blood Transfusion

Blood transfusion is given without delay (within 4 hours) in case of hemoglobin below our threshold.

OTHER

Standard care

These patients recieve our standard care including blood transfusion as usual. Vital parameters and delirium screening are collected three times a day.

Sponsors & Collaborators

  • Gødstrup Hospital

    collaborator OTHER

  • Aarhus University Hospital

    collaborator OTHER

  • University of Aarhus

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-04-24
Primary Completion
2026-12-31
Completion
2027-06-01

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06938789 on ClinicalTrials.gov