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Daily Nitrofurantoin Versus Bladder Fulguration Plus Daily Nitrofurantoin for Women With Recurrent Urinary Tract Infections

NCT06907199 · Status: RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 104

Last updated 2026-05-01

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if the drug Nitrofurantoin (NF) taken as a daily antibiotic, works to treat cystitis compared to electrofulguration (EF) and Nitrofurantoin (NF) daily antibiotic.

Conditions

  • Recurrent UTIs
  • Cystitis Recurrent

Interventions

PROCEDURE

Electrofulguration (EF)

Nitrofurantoin (NF) daily antibiotic prophylaxis for 6 months plus Electrofulguration.

DRUG

Nitrofurantoin (NF)

Nitrofurantoin (NF) daily antibiotic prophylaxis given daily for 6 months.

Sponsors & Collaborators

  • University of Texas

    collaborator OTHER

  • National Institutes of Health (NIH)

    collaborator NIH

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    collaborator NIH

  • University of Texas Southwestern Medical Center

    lead OTHER

Principal Investigators

  • Philippe Zimmern, M.D. · University of Texas Southwestern Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-06
Primary Completion
2028-07-01
Completion
2029-01-30
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06907199 on ClinicalTrials.gov