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A Trial of D-mannose for the Prophylaxis of Recurrent Urinary Tract Infections

NCT06940622 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2025-09-22

No results posted yet for this study

Summary

A randomized, double-blind, placebo-controlled, 12-month study to determine the effectiveness of D-mannose (2g daily) supplementation in rUTI (recurrent urinary tract infection) prevention in post-menopausal women.

Conditions

  • Recurrent UTIs
  • Recurrent Urinary Tract Infections
  • Recurrent Urinary Tract Infections in Women
  • Recurrent Urinary Tract Infection
  • Cystitis Recurrent
  • Cystitis Chronic
  • UTI
  • UTI - Urinary Tract Infection
  • UTI - Lower Urinary Tract Infection

Interventions

DIETARY_SUPPLEMENT

D-Mannose

D-mannose (2g, i.e., 4 x 500mg capsules) daily for 12 months.

DIETARY_SUPPLEMENT

Placebo

Placebo daily for 12 months.

Sponsors & Collaborators

  • University of Texas Southwestern Medical Center

    lead OTHER

Principal Investigators

  • Philippe Zimmern, MD · University of Texas Southwestern Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
55 Years
Max Age
85 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-08-01
Primary Completion
2029-09-30
Completion
2030-09-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06940622 on ClinicalTrials.gov