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A Study That Collects Participant Data and Biospecimens to Analyze Pathogenic Exosomes That Mediate Increased Vascular Dementia Risk in Individuals With Herpes Zoster.

NCT06903078 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 375

Last updated 2025-12-11

No results posted yet for this study

Summary

The purpose of this observational research study is to study if patients with herpes zoster, also known as Shingles, have a higher risk of vascular dysfunction (problems with blood vessels, including stroke) and vascular dementia (problems with mental decline as a result of decreased blood flow to the brain) compared to patients without herpes zoster.

Patients are evaluated based on the group they are assigned too:

1. Herpes Zoster (HZ) Group: individuals presenting with untreated herpes zoster. These participants will have 6 visits:

* Day 1 = 1st day presenting to clinic with acute zoster
* 7 days post zoster
* 1 month after Day 1
* 3 months after Day 1
* 6 months after Day 1
* 12 months after Day 1
2. Control Group: individuals without herpes zoster o Day 1 (only 1 visit will be completed)

This study does not have a study medication/device. Standard of care for all patients will be followed.

Conditions

  • Herpes Zoster (HZ)
  • Vascular Dementia

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • Center for Clinical Studies, Texas

    lead OTHER

Principal Investigators

  • Project Director · University of Colorado, Denver

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-02-13
Primary Completion
2029-07-31
Completion
2030-08-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06903078 on ClinicalTrials.gov