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Lung Atelectasis Improvement Through Positive End Expiratory Pressure During Anesthetic Induction

NCT06900426 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2025-05-29

No results posted yet for this study

Summary

Anesthetic induction could lead to lung atelectasis, increase intrapulmonary shunt, and potentially impair oxygenation. The study aimed to validate that a positive end-expiratory pressure (PEEP) of 10 cmH2O could reduce lung atelectasis, comparing to 0 or 5 cmH2O with limited overdistension.

Conditions

  • Lung Injury, Acute

Interventions

OTHER

10 PEEP

Using 10cmH2O PEEP during anesthetic induction monitored by EIT.

OTHER

ZEEP

No PEEP

OTHER

5PEEP

Using 5cmH2O PEEP

Sponsors & Collaborators

  • Fudan University

    lead OTHER

Principal Investigators

  • Jun Zhang, Professor · Fudan University Shanghai Cancer Centre

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-03-28
Primary Completion
2025-04-28
Completion
2025-04-28

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06900426 on ClinicalTrials.gov