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Exploring the Influence of Trptophan on the Treatment of Pouchitis

NCT06861140 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2025-03-06

No results posted yet for this study

Summary

Patients with a pouch frequently suffer from chronic inflammation of the intestinal tract, called pouchitis. Pouchitis is routienly treated with repeated courses of antibiotics and probiotics, which does not stop the inflammation from recurring and exposes the patients to the risk of developing antibiotic -resistant pouchitis. Experimental data suggest that the effectiveness of the antibiotic and probiotic treatment can be prolonged by high consumption of trypotophan, an aminoacid present in everyday food. The Try Pro Pouch study aims to compare the consumption of high amounts of tryptophan against placebo in patients with pouchitis.

Conditions

  • Pouchitis

Interventions

DIETARY_SUPPLEMENT

Tryptophan 25mg/kg bodyweight

Tryptophan is supplemented during the treatment of chronic pouchitis with pro- and antibiotics

OTHER

Placebo

standard treatment of chronic pouchitis using pro- and antibiotics.

Sponsors & Collaborators

  • Universitätsklinikum Hamburg-Eppendorf

    lead OTHER

Principal Investigators

  • Samuel Huber, Prof. Dr. med. · Universitätsklinkum Hamburg-Eppendorf, I. Medizinische Klinik und Poliklinik

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-04-01
Primary Completion
2027-04-30
Completion
2027-04-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06861140 on ClinicalTrials.gov