Real-World Study of Chidamide Combined With PD-(L)1 Inhibitors and Anti-Angiogenic Therapy for Advanced MSS-Type Colorectal Cancer
NCT06858956 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 200
Last updated 2025-03-05
Summary
This is an observational , multicenter, real-world study aimed at evaluating the efficacy and safety of the combination of immune checkpoint inhibitors, chidamide and antiangiogenic agents in Microsatellite Stable advanced colorectal cancer patients.
Conditions
Interventions
- DRUG
-
Chidamide, Tucidinostat; PD-1/PD-L1 inhibitor or double antibodies; Bevacizumab or tyrosine kinase inhibitors
Chidamide, Tucidinostat; PD-1/PD-L1 inhibitor or double antibodies; Bevacizumab or tyrosine kinase inhibitors
Sponsors & Collaborators
-
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
lead OTHER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-03-01
- Primary Completion
- 2025-05-31
- Completion
- 2026-05-31
More Related Trials
-
Tirellizumab+Anlotinib VS Anlotinib for MSS-type CRC
NCT06573424 ·Status: COMPLETED
-
Neoadjuvant Cadonilimab Plus Chemotherapy Following Short-Course Radiotherapy in Locally Advanced Rectal Cancer
NCT05792735 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II RCT of LCRT vs SCRT + CAPOX/PD-1i/COX-2i in MSS Locally Advanced Rectal Cancer
NCT07154316 ·Status: RECRUITING ·Phase: PHASE2
-
Patient-reported Outcomes (PRO) and Treatment Outcomes of Chinese Patients With MSS-type Advanced Colorectal Cancer Who Received the Zidovudine Combination Regimen in the Real World
NCT07105631 ·Status: RECRUITING
-
SBRT Combined With CAPEOX, Bevacizumab, and PD-1 Inhibitor for the Treatment of RAS-Mutant, MSS-Type, Unresectable Metastatic Colorectal Cancer.
NCT06835179 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Total Neoadjuvant Therapy With Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Ultra Low Rectal Adenocarcinoma
NCT05858567 ·Status: UNKNOWN ·Phase: PHASE2
-
The Combination of Immunotherapy and Neoadjuvant Chemoradiotherapy in MSS Locally Advanced Rectal Cancer
NCT04411537 ·Status: UNKNOWN ·Phase: PHASE2
-
Organ Preservation Strategy of Total Neoadjuvant Chemoradiotherapy for Low Rectal Carcinoma
NCT05563922 ·Status: RECRUITING ·Phase: PHASE2
-
Oral Chemotherapy, Targeted Therapy and Immunotherapy With/Without Radiotherapy as 3rd- or Later-line Therapy for Advanced MSS/pMMR Colorectal Cancer
NCT06764680 ·Status: RECRUITING ·Phase: PHASE2
-
High-activity Natural Killer Immunotherapy for Small Metastases of Colorectal Cancer
NCT03008499 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Node-sparing Radiotherapy Combined With Total Neoadjuvant CAPOX and Sintilimab for MSS Middle and Low Rectal Cancer
NCT06204094 ·Status: RECRUITING ·Phase: PHASE2
-
Total Neoadjuvant Therapy With PD-1 for Locally Advcancer Rectal Cancer
NCT07214142 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
PD1 Antibody Toripalimab and Chemoradiotherapy for dMMR/MSI-H Locally Advanced Colorectal Cancer
NCT04301557 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
PD-1 Antibody Following Preoperative Chemoradiotherapy for Locally Advanced pMMR/MSS Rectal Cancer
NCT04833387 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Nodes-sparing Short-course Radiation Combined With CAPOX and Tislelizumab for MSS Middle and Low Rectal Cancer
NCT05972655 ·Status: RECRUITING ·Phase: PHASE2
-
PD-1-M1-NK Cells in the Treatment of Advanced Gastric or Colorectal Cancer
NCT07031011 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
Short-course Radiotherapy Combined With Chemotherapy and Pd-1 Inhibitor for Locally Advanced Colon Cancer(TORCH-C)
NCT05732493 ·Status: UNKNOWN ·Phase: PHASE2
-
Impact of Body Mass Index and Lipid Metabolism on Anti-PD-1 Immunotherapy Outcomes in Colorectal Cancer
NCT07012174 ·Status: COMPLETED
-
FMT+Immunotherapy+Chemotherapy As First-line Treatment for Driver-gene Negative Advanced NSCLC
NCT06403111 ·Status: RECRUITING ·Phase: PHASE2
-
Node-Sparing Low-Dose Radiotherapy Concurrent With Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Single-Arm, Phase II Trial
NCT07279077 ·Status: RECRUITING ·Phase: PHASE2
-
Induction Chemotherapy Combined With Neoadjuvant Immunotherapy for MSS Colon Cancer
NCT05914389 ·Status: RECRUITING ·Phase: PHASE2
-
Efficacy of Combination Immunotherapy in Patients With Metastatic Colorectal Cancer
NCT05414461 ·Status: COMPLETED ·Phase: PHASE2
-
Neoadjuvant Therapy for Locally Advanced Rectal Cancer
NCT06853769 ·Status: ACTIVE_NOT_RECRUITING ·Phase: EARLY_PHASE1
-
Neoadjuvant Chemotherapy With PD-1 Inhibitors Combined With SIB-IMRT in the Treatment of Locally Advanced Rectal Cancer
NCT06017583 ·Status: RECRUITING ·Phase: PHASE3
-
NALIRIFOX Plus Targeted Therapy Versus FOLFOX Plus Targeted Therapy as First-line Treatment for Metastatic Colorectal Cancer
NCT07309289 ·Status: RECRUITING ·Phase: PHASE3