MedTrace Logo

A Study to Improve Skeletal Muscle in Veterans With HIV

NCT06845046 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2025-07-30

No results posted yet for this study

Summary

The Department of Veterans Affairs is the largest single provider of medical care to people with HIV in the United States. The condition of excess lipid within and around muscle, termed myosteatosis, predisposes Veterans to physical function decline, frailty, disability, and cardiometabolic diseases such as diabetes and cardiovascular disease. In the investigators current Merit supported cohort, the investigators found that 36% of Veterans with treated HIV and obesity have "myosteatotic type obesity". Based on the investigators findings, the investigators have designed a multipronged integrated intervention that combines: 1) dietary replacement of saturated with unsaturated fats; 2) administration of L-carnitine and omega-3 fatty acid supplementation; and 3) targeted resistance exercise training.

Conditions

Interventions

DIETARY_SUPPLEMENT

w-3 fatty acid

omega-3 fatty acid supplement

DIETARY_SUPPLEMENT

L-carnitine

L-carnitine supplement

OTHER

Control Diet

Control Diet high in unsaturated fat

Sponsors & Collaborators

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Heidi J Silver, PhD · Tennessee Valley Healthcare System Nashville Campus, Nashville, TN

  • John R Koethe, MD · Tennessee Valley Healthcare System Nashville Campus, Nashville, TN

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
FACTORIAL

Eligibility

Min Age
20 Years
Max Age
80 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-15
Primary Completion
2029-06-29
Completion
2029-06-29

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06845046 on ClinicalTrials.gov