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Opioid Use Disorder and Pain

NCT06800703 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 180

Last updated 2025-02-28

No results posted yet for this study

Summary

The goal of this observational study is to characterize the brain processes of pain avoidance learning dysfunctions in individuals with opioid use disorder (OUD). The main questions it aims to answer are:

Compared with healthy controls, do those with OUD exhibit impaired avoidance learning in response to pain? What are the brain processes that are associated with this avoidance learning dysfunction? Do these brain processes serve to predict future use or relapse?

Researchers will compare those with OUD and healthy controls to determine avoidance learning dysfunction and its relationship with opioid use.

Participants will be performing a learning task inside an fMRI scanner. Those with OUD will also be followed up for a year to determine future opioid use.

Conditions

Interventions

BEHAVIORAL

follow up interviews for 12 months to determine opioid use

Follow-up

Sponsors & Collaborators

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    collaborator NIH

  • Brain and Behavior Research Foundation (previously known as NARSAD)

    collaborator UNKNOWN

  • Yale University

    lead OTHER

Principal Investigators

  • Thang M Le, PhD · Yale University

Eligibility

Min Age
21 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-02-04
Primary Completion
2028-01-31
Completion
2028-01-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06800703 on ClinicalTrials.gov