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COMMUNITY - the COVID-19 Immunity Study

NCT06784739 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 5500

Last updated 2025-01-20

No results posted yet for this study

Summary

The principal aim of the COMMUNITY study is to investigate immune responses following SARS-CoV-2 infection and/or vaccination in healthcare workers and hospitalized COVID-19 patients. The study aims to enroll a total of 5,000 healthcare workers and 500 COVID-19 patients. All participants are enrolled at Danderyd Hospital in Stockholm, Sweden. Participants will be followed every four months with blood and mucosal sampling in addition to demographic and clinical data provided by the participants and from national registries.

Primary outcome:

\- Antibody responses in blood and mucosa following SARS-CoV-2 infection and/or vaccination

Secondary outcomes:

* Cellular immune responses following SARS-CoV-2 infection and/or vaccination
* Antibody responses in blood and mucosa following following Influenza A/B infection and/or vaccination
* Antibody responses in blood and mucosa following following RSV A/B infection

Blood and mucosal samples are collected every 4 months and at tighter intervals in sub studies. PCR testing is conducted upon symptoms of respiratory infections and with regular intervals regardless of symptomatology in sub studies. Participants provide detailed demographic and clinical data through a smart phone application-based questionnaire. Data on infection and vaccination history is collected from national registries

Conditions

  • COVID 19
  • Respiratory Synctial Virus
  • Influenza Virus
  • SARS-CoV-2 Virus

Interventions

OTHER

Blood sampling

Venous blood sampling

OTHER

Mucosal sampling

Saliva and nasal secretions

DIAGNOSTIC_TEST

PCR-test

RT qPCR test to determine infection with SARS-CoV-2, Influenza A/B and/or RSV A/B.

Sponsors & Collaborators

  • Danderyd Hospital

    lead OTHER

Principal Investigators

  • Charlotte Thålin, MD, PhD · Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-04-15
Primary Completion
2027-04-30
Completion
2027-04-30

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06784739 on ClinicalTrials.gov