COVID-19: Investigation of Transmission and Immunisation Among Hospital Staff

Summary

During the COVID-19 pandemic several countries have seen a high risk of transmission for health care personnel, with some countries having as many 20-25% of nurses and doctors either infected or showing symptoms of COVID-19.

In this prospective cohort study, we will systematically screen all hospital staff in the Capital Region of Denmark for IgM and IgG antibodies against SARS-CoV-2 using a point of care tests and an Elisa kit.

Testing will be offered 3 times: In April 2020, Maj 2020 and September 2020. All participants will submit a questionnaire regarding exposures, risk factors and symptoms of COVID-19 in relation to each testing. Follow-up will be through electronic patient records and national registries.

We will compare the group of health care personnel with data from a control group of healthy volunteer blood donors from the Danish Blood Donor Study.

The aim of the study is to investigate the proportion of hospital staff with SARS-CoV-2 antibodies during the study period compared to a control group representing the Danish population. We will compare the test characteristics of the two methods of testing, a point of care test and Elisa.

Further, we will investigate the extent to which prior immunization or infection is protective for future infection with COVID-19.

Conditions

• COVID

Interventions

DIAGNOSTIC_TEST

IgM and IgG diagnostic kits to SARS-CoV-2

Diagnostic kits for IgM/IgG antibodies to SARS-CoV-2

DIAGNOSTIC_TEST

Elisa-test for IgM and IgG to SARS-CoV-2

Elisa-test for IgM and IgG to SARS-CoV-2

Sponsors & Collaborators

• Nordsjaellands Hospital

  collaborator OTHER

• Hvidovre University Hospital

  collaborator OTHER

• Rigshospitalet, Denmark

  collaborator OTHER

• Mental Health Services in the Capital Region, Denmark

  collaborator OTHER

• University Hospital Bispebjerg and Frederiksberg

  collaborator OTHER

• Herlev Hospital

  lead OTHER

Principal Investigators

• Kasper Iversen, Prof. · Herlev-Gentofte Hospital

• Henning Bundgaard, Prof. · Rigshospitalet, Denmark

• Henrik Ullum, Prof. · Rigshospitalet, Denmark

• Thomas Benfield, Prof. · Hvidovre University Hospital

• Susanne Dam Poulsen, Prof. · Rigshospitalet, Denmark

• Jørgen Rungby, Prof. · Bispebjerg Hospital

• Fredrik Folke, Associate prof. · Akutberedskabet

• Thea Kølsen Fischer · Nordsjaellands Hospital

• Ove Andersen, Prof. · Hvidovre University Hospital

• Ida Hageman · Mental Health Services in the Capital Region, Denmark

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-04-15

Primary Completion

2020-10-07

Completion

2020-10-07

Countries

• Denmark

Study Locations