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Screening for COVID-19 and Monitoring of Serological Responses to SARS-CoV-2 in Healthcare Workers

NCT04370119 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1092

Last updated 2025-11-20

No results posted yet for this study

Summary

The main objectives of this study are 1) to establish the prevalence of SARS-CoV-2 in asymptomatic healthcare workers (HCWs) in an early phase of community spread as well as 2) to monitor the future spread of the disease by assessing serological responses to SARS-CoV-2 in symptomatic and asymptomatic HCWs over time and 3) to improve the assessment of the immune response and its protective effect as well as the assessment of infectivity of affected HCWs and 4) to evaluate the value and significance of antibody formation and serological antibody tests and 5) to be able to evaluate possible future preventive and / or therapeutic approaches against SARS-CoV-2, e.g. to assess vaccination effects

Conditions

Interventions

DIAGNOSTIC_TEST

Nasal swab

SARS-CoV-2 PCR

DIAGNOSTIC_TEST

Serum testing

Anti-SARS-CoV2 S protein IgG ELISA, serological changes after SARS-CoV-2 vaccination

Sponsors & Collaborators

  • Friedrich Loefler Institute for Animal Health

    collaborator UNKNOWN

  • EUROIMMUN AG

    collaborator UNKNOWN

  • University Medicine Greifswald

    lead OTHER

Principal Investigators

  • Nils-Olaf Hübner, Prof.Dr. · University Medicine Greifswald

  • Karsten Becker, Prof.Dr. · University Medicine Greifswald

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-04-27
Primary Completion
2021-04-23
Completion
2025-04-27

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04370119 on ClinicalTrials.gov