A Clinical Study to Explore the Safety and Efficacy of CD33 CAR-T Cell in Relapsed/Refractory Acute Myeloid Leukemia
NCT06762132 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 27
Last updated 2025-01-07
Summary
A Clinical Study on the Safety and Effectiveness of targeting CD33 CAR-T Cell in the treatment of Relapsed/Refractory Acute Myeloid Leukemia
Conditions
Interventions
- BIOLOGICAL
-
CD33 CAR T-cells
Each subject receive CD33 CAR T-cells by intravenous infusion
Sponsors & Collaborators
-
Yake Biotechnology Ltd.
collaborator INDUSTRY -
Zhejiang University
lead OTHER
Principal Investigators
-
He Huang, MD · First Affiliated Hospital of Zhejiang University
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-01-10
- Primary Completion
- 2027-10-30
- Completion
- 2027-10-30
Countries
- China
Study Locations
More Related Trials
-
Treatment of Relapsed and/or Chemotherapy Refractory CD33 Positive Acute Myeloid Leukemia by CART-33
NCT01864902 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
APRIL CAR-T Cell Therapy for Patients With BCMA/TACI Positive Relapsed and/or Refractory Multiple Myeloma
NCT04657861 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
IL3 CAR-T Cell Therapy for Patients With CD123 Positive Relapsed and/or Refractory Acute Myeloid Leukemia
NCT04599543 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
A Study of CT0596 in Relapsed/Refractory Multiple Myeloma and Relapsed/ Refractory Plasma Cell Leukemia
NCT06730256 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Anti-CD33 CAR-T Cells for the Treatment of Relapsed/Refractory CD33+ Acute Myeloid Leukemia
NCT05445765 ·Status: UNKNOWN ·Phase: PHASE1
-
NKG2D CAR-T Cell Therapy for Patients With Relapsed and/or Refractory Acute Myeloid Leukemia
NCT04658004 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
Clinical Study on the Safety and Efficacy of CD7 CAR-T Cell in Patients With Relapsed/Refractory Acute Leukemia
NCT06585345 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of Humanized BCMA-targeted CAR-T Cells Therapy for Refractory/Relapsed Multiple Myeloma
NCT04670055 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
A Study of BCMA-targeted CAR-T Cells Therapy for Refractory/Relapsed Multiple Myeloma
NCT05430945 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
CD79b CAR-T Cell Therapy for Patients With Relapsed and/or Refractory Acute Lymphoblastic Leukemia and B-cell Non-Hodgkin's Lymphoma
NCT04609241 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
A Study of BCMA CAR-T Cell Therapy for Newly Diagnosed Multiple Myeloma
NCT05712083 ·Status: UNKNOWN ·Phase: PHASE2
-
Clinical Study on the Safety and Efficacy of Autologous CD84 Chimeric Antigen Receptor T-Cell Therapy for Adult Relapsed/Refractory Acute Myeloid Leukemia.
NCT06786299 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
Clinical Study of CAR-BCMA T in Patients With Refractory or Relapsed Multiple Myeloma
NCT03716856 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study of CS1-targeted CAR-T Cells Therapy for Relapsed Multiple Myeloma After BCMA CAR-T Cells Therapy
NCT04541368 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
Evaluate the Safety and Efficacy of CLL1+CD33 CAR-T in Patients With R/R AML
NCT05467254 ·Status: UNKNOWN ·Phase: PHASE1
-
Targeting CD5 CAR-T Cells in the Treatment of r/r CD5+ T-ALL
NCT06633354 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
A Clinical Study to Explore the Safety and Efficacy of CT0991 in Relapsed/Refractory Acute Myeloid Leukemia
NCT06709131 ·Status: SUSPENDED ·Phase: PHASE1
-
CART-123 FOR Relapsed/Refractory Acute Myelocytic Leukemia(AML)
NCT03556982 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
a Clinical Research of BCMA-Targeted Prime CAR-T Cell Therapy in Relapsed/Refractory Multiple Myeloma and Plasma Cell Disease
NCT04776330 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Optimized Dual CD33/CLL1 CAR T Cells in Subjects With Refractory or Relapsed Acute Myeloid Leukemia
NCT05248685 ·Status: WITHDRAWN ·Phase: PHASE1
-
Anti-CD22 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy for Relapsed Refractory B-cell Malignancies
NCT04007978 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study of A-CAR028 Treatment in Subjects With Relapsed or Refractory Acute Myeloid Leukemia
NCT07198867 ·Status: RECRUITING ·Phase: PHASE1
-
Donor-derived CAR-T Cells in the Treatment of AML Patients
NCT04766840 ·Status: UNKNOWN ·Phase: PHASE1
-
Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART133
NCT02541370 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of CAR T-Cells in Relapsed/Refractory Hematologic Malignancy
NCT06756321 ·Status: RECRUITING ·Phase: EARLY_PHASE1