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rTMS Combined With Motor Training for the Treatment of Upper Limb Motor Dysfunction in Stroke Patients

NCT06752499 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-04-30

No results posted yet for this study

Summary

The goal of this clinical trials is to investigate the effectiveness of online repetitive transcranial magnetic stimulation (rTMS) in enhancing upper limb motor rehabilitation during the subacute and chronic phase of stroke. It will also learn about the safety of online rTMS intervention methods. The main questions it aims to answer are:

1. Does rTMS combined with motor training improve motor rehabilitation in patients？
2. Does repetitive transcranial magnetic stimulation (rTMS) combined with motor training enhance the upper limb motor rehabilitation ability in stroke patients by strengthening the functional coupling of the motor circuit to achieve functional reorganization of the brain network ?

Researchers will compare online rTMS to offline and sham stimulation in stroke patients to see if online rTMS works to alleviate motor dysfunction in multicenter multicenter, blinded and controlled trial.

Participants will:

1. randomized to one group(online, offline or sham);
2. receive rTMS treatment for 10 days, with 5 working days per week for a total of two weeks;
3. receive magnetic resonance imaging (MRI) and electroencephalogram (EEG) evaluations before and after the entire treatment;
4. conduct scales and MEP assessment one day before the treatment, as well as one day, one month, and three months after the treatment.

Conditions

  • Stroke
  • Upper Extremity Paresis

Interventions

DEVICE

Online stimulation

5 Hz rTMS is applied to the primary motor cortex on the affected hemisphere when the patients are performing motor tasks.

DEVICE

Offline stimulation

After 5 Hz rTMS is applied to the primary motor cortex on the affected hemisphere, the patients perform motor tasks.

DEVICE

Sham stimulation

Sham rTMS is applied to the primary motor cortex on the affected hemisphere when the patients are performing motor tasks.

Sponsors & Collaborators

  • Changhai Hospital

    collaborator OTHER

  • Shanghai Sunshine Rehabilitation Center

    collaborator OTHER

  • shanghai center for brain science and brain-inspired technology

    collaborator UNKNOWN

  • Ruijin Hospital

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-20
Primary Completion
2025-09-10
Completion
2025-09-10

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06752499 on ClinicalTrials.gov