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Repetitive Transcranial Magnetic Stimulation Combined With Bimanual Therapy for Upper Limb Stroke Rehabilitation

NCT07054424 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 54

Last updated 2025-07-08

No results posted yet for this study

Summary

The goal of this clinical trial is to evaluate whether combining repetitive transcranial magnetic stimulation (rTMS) with machine-assisted bimanual therapy (BT) can improve upper limb function in stroke patients. The participants will be individuals aged 40-80 years who have experienced a first-time ischemic or hemorrhagic stroke. The main questions it aims to answer are:

* Does the combined therapy enhance motor recovery compared to traditional rehabilitation methods?
* Are changes in brain activity associated with improvements in upper limb function?

Participants will be randomly assigned to different groups and will:

* Receive rTMS stimulation on specific areas of the brain to modulate neural activity,
* Perform machine-assisted bimanual exercises to promote motor skills, and
* Undergo assessments before, immediately after, and during follow-up periods to measure functional improvements.

Conditions

  • Post-stroke Upper Limb Hemiparesis
  • Repetitive Transcranial Magnetic Stimulation (rTMS)
  • Bimanual Therapy
  • Neuromodulation

Interventions

OTHER

Conventional occupation therapy

Standard occupational therapy focused on improving daily functional skills through task-specific training and adaptive techniques.

OTHER

stretching exercise

Techniques involving passive or active stretching of muscles to enhance flexibility, reduce spasticity, and prevent contractures.

OTHER

rTMS

Non-invasive brain stimulation method using magnetic pulses to modulate cortical excitability and promote neural plasticity.

DEVICE

bimanual therapy

A training approach that involves simultaneous use of both hands to enhance coordination and functional hand movements through guided exercises, including device-assisted and robot-assisted therapy

Sponsors & Collaborators

  • Chang Gung Memorial Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-15
Primary Completion
2027-07-31
Completion
2027-07-31

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07054424 on ClinicalTrials.gov