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Radiographic and Histological Assessment of GBR Using DBB Compared to Spontaneous Bone Regeneration of Maxillary Defects , Resulted From Enucleation of Intra-bony Cystic Lesions

NCT06749158 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 44

Last updated 2026-03-27

No results posted yet for this study

Summary

Two groups of patients with maxillary defects resulted from enucleation of intra-bony cystic lesions the 1st group will be subjected to guided bone regeneration while the second group will be subjected to spontaneous bone regeneration.

Conditions

  • Maxillary Cyst

Interventions

PROCEDURE

spontaneous bone regeneration

stage 1 surgery: 1. after administration of Local anesthesia (Articaine hydrochloride 4% with Epinephrine 1:100,000 injectable solution), sulcular incision will be done , extending two teeth beyond the area of interest followed by two oblique incisions on either side of the flap 2. after flap elevation, enucleation of the cystic lesion and extraction of the non-restorable teeth related to the lesion will be done. 3. titanium mesh will be tailored with 3 mm overlap at the edges to cover the bone window completely and fixed to the bone using mono-cortical titanium screws. This will be followed by: Primary closure using 4-0 vicryl sutures that will be removed 10 days postoperatively. stage 2 surgery(after 6 months): 1. titanium mesh and screws will be removed. 2. core biopsy will be obtained for histological assessment 3. dental implant/s placement for cases indicated for implantation.

PROCEDURE

guided bone regeneration

stage 1 surgery after cyst enucleation and extraction of the non-restorable teeth related to the lesion, The intra-bony defect will be filled with Deproteinized Bovine Bone. -Titanium mesh will be tailored with 3mm overlap at the edges to cover the bone window completely and fixed to the bone using mono-cortical titanium screws. This will be followed by Primary closure using 4-0 vicryl sutures that will be removed 10 days postoperatively. stage 2 surgery(6 months later) : 1. titanium mesh will be removed. 2. core biopsy will be obtained for histological assessment. 3. dental implant/s placement for cases indicated for implantation.

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Principal Investigators

  • Mohamed A Abdelrasoul, PhD · faculty of oral and dental medicine, Cairo university

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-12-30
Primary Completion
2025-12-30
Completion
2026-02-01

Countries

  • Egypt

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06749158 on ClinicalTrials.gov