Probing the Role of Feature Dimension Maps in Visual Cognition: Impact of Working Memory Maintenance (Expt 2.3)

Summary

How does one know what to look at in a scene? Imagine a "Where's Waldo" game - it's challenging to find Waldo because there are many 'salient' locations in the picture, each vying for one's attention. One can only attend to a small location on the picture at a given moment, so to find Waldo, one needs to direct their attention to different locations. One prominent theory about how one accomplishes this claims that important locations are identified based on distinct feature types (for example, motion or color), with locations most unique compared to the background most likely to be attended. An important component of this theory is that individual feature dimensions (again, color or motion) are computed within their own 'feature maps', which are thought to be implemented in specific brain regions. However, whether and how specific brain regions contribute to these feature maps, along with their role in supporting memory of visual information over brief delays, remains unknown.

The goal of this study is to determine how brain regions that respond strongly to different feature types (color and motion) and which encode spatial locations of visual stimuli contribute to memory of visual features. Based on previous studies, the investigators hypothesize that feature-selective brain regions act as neural feature dimension maps, and thus encode representations of relevant location(s) based on their preferred feature dimension, such that the stimulus representation in the most relevant feature map is maintained over a memory delay period to support adaptive behavior. The investigators will scan healthy human participants using functional MRI (fMRI) in a repeated-measures design while they view and remember different features of visual stimuli (e.g., color or motion). The investigators will employ state-of-the-art multivariate analysis techniques that allow them to reconstruct an 'image' of the stimulus representation encoded by each brain region to dissect how neural tissue identifies salient locations. Each participant will recall the remembered feature value (color or motion) of a stimulus presented in the periphery. Across trials the investigators will manipulate the remembered feature value (color, motion, or attend to nothing). This manipulation will help the investigators fully understand these critical relevance computations in the healthy human visual system.

Conditions

• Basic Science: Visual Attention in Healthy Participants
• Basic Science: Neural Representations of Location

Interventions

OTHER

Stimulus properties: remembered feature

The feature used to determine which stimulus feature to remember to will be varied across trials using a letter cue (M = remember-motion; C = remember-color; 0 = remember nothing)

Sponsors & Collaborators

• National Eye Institute (NEI)

  collaborator NIH

• University of California, Santa Barbara

  lead OTHER

Principal Investigators

• Tommy C Sprague · University of California, Santa Barbara

Study Design

Allocation

NA

Purpose

BASIC_SCIENCE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

55 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-04-16

Primary Completion

2025-02-05

Completion

2025-02-05

Countries

• United States

Study Locations