Effect of Premedication With Pronase on Mucosal Cleanliness During EGD

Summary

Gastric cancer and esophageal cancer are common malignant tumors that threaten people's life and health. Esophagogastroduodenoscopy (EGD) is an important tool for screening upper gastrointestinal tumors, especially early tumors, and an effective method for detecting other upper gastrointestinal lesions, including ulcers and polyps. However, during EGD examination, mucus and foam can reduce the cleanliness of the mucosa and limit the operator's visual field, resulting in missed lesions and misdiagnosis. Previous studies have shown that preoperative medication with pronase and dimeticone is correlated with the improvement of upper gastrointestinal mucosal cleanliness. However, the number of samples in such studies is limited, and the artificial judgment is not objective enough to evaluate the cleanliness of upper digestive tract mucosa. And, whether a postural exercise is necessary for premedication with pronase or dimeticone remains unclear. Our team design this experiment to examine the efficacy of using premedication of dimeticone/pronase with a postural exercise on visualization of the mucosa before painless EGD. The investigators aim to provide new evidence to optimize the use of premedication with EGD.

Conditions

• Esophageal Cancer
• Gastric Cancer

Interventions

DRUG

Dimethicone+Pronase

Approximately 15-20 minutes before EGD, patients orally receive 50mL of warm water containing 5g dimethicone powder and 20,000 IU pronase granules combined with 1 g NaHCO3.

DRUG

Dimethicone

Approximately 15-20 minutes before EGD, patients orally receive 50mL of warm water containing 5g dimethicone powder.

BEHAVIORAL

with Postural Exercise

After the premedication is administered orally approximately 15-20 minutes before EGD, patients are asked to take a 3-minute postural exercise.

BEHAVIORAL

without Postural Exercise.

After the premedication is administered orally approximately 15-20 minutes before EGD, patients sit quietly awaiting examination.

Sponsors & Collaborators

• Fujian Provincial Hospital

  collaborator OTHER

• Huashan Hospital

  collaborator OTHER

• The Second Affiliated Hospital of Harbin Medical University

  collaborator OTHER

• First Affiliated Hospital of Harbin Medical University

  collaborator OTHER

• Red Cross Hospital, Hangzhou, China

  collaborator OTHER

• The Affiliated Hospital of Inner Mongolia Medical University

  collaborator OTHER

• Yuebei People's Hospital

  collaborator OTHER

• Longgang District People's Hospital of Shenzhen

  collaborator OTHER

• Huadu District People's Hospital of Guangzhou

  collaborator OTHER

• Liaocheng People's Hospital

  collaborator OTHER

• Qilu Hospital of Shandong University

  collaborator OTHER

• The Second Affiliated Hospital of Shandong First Medical University

  collaborator OTHER

• Anqing Municipal Hospital

  collaborator OTHER

• Jiujiang No.1 People's Hospital

  collaborator OTHER

• Kunshan Hospital of Traditional Chinese Medicine

  collaborator UNKNOWN

• Nanjing Gaochun People's Hospital

  collaborator OTHER

• Taizhou First People's Hospital

  collaborator OTHER

• Hengshui People's Hospital

  collaborator OTHER

• Affiliated Hospital of Hebei University

  collaborator OTHER

• Second Affiliated Hospital of Xi'an Jiaotong University

  collaborator OTHER

• Taihe Hospital

  collaborator OTHER

• ZhuZhou Central Hospital

  collaborator OTHER

• The Second Affiliated Hospital of Kunming Medical University

  collaborator OTHER

• First Affiliated Hospital of Kunming Medical University

  collaborator OTHER

• Subei People's Hospital of Jiangsu Province

  collaborator OTHER

• The Affiliated Hospital Of Southwest Medical University

  collaborator OTHER

• The Second Affiliated Hospital of Chongqing Medical University

  collaborator OTHER

• Loudi Central Hospital

  collaborator OTHER

• Beijing Tiantan Hospital

  collaborator OTHER

• Peking Union Medical College Hospital

  collaborator OTHER

• The First People's Hospital of Lin'an District, Hangzhou

  collaborator UNKNOWN

• Zhejiang Provincial People's Hospital

  collaborator OTHER

• Jining Medical University

  collaborator OTHER

• Ningbo Medical Center Lihuili Hospital

  collaborator OTHER_GOV

• Zhoushan Hospital, Zhejiang

  collaborator UNKNOWN

• General Hospital of Ningxia Medical University

  collaborator OTHER

• Yunnan Cancer Hospital

  collaborator OTHER

• Xinghua City People's Hospital

  collaborator UNKNOWN

• Beijing Friendship Hospital, Captial Medical University

  collaborator UNKNOWN

• Beijing Chao-Yang Hospital, Captial Medical University

  collaborator UNKNOWN

• The People's Hospital of JiangMen

  collaborator UNKNOWN

• The First People's Hospital of TianMen in Hubei Province

  collaborator UNKNOWN

• THE FIRST AFFILIATED HOSPITAL OF SHIHEZI UNIVERSITY

  collaborator UNKNOWN

• Changhai Hospital

  lead OTHER

Principal Investigators

• Luowei Wang, MD · Changhai hosipital, Shanghai

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Model

FACTORIAL

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-12-01

Primary Completion

2025-09-01

Completion

2025-09-01

Countries

• China

Study Locations