The Role of Extracellular DNA (ecDNA) in the Occurrence and Development of Gastric

Summary

ECDNA is almost non-existent in normal cells, but exists in nearly half of human cancer cells, indicating that studying such abnormal DNA is of great significance for our understanding of tumor formation and evolution. The changes in ecDNA expression in intestinal type gastric cancer may be closely related to the occurrence and development of gastric cancer. Dynamic monitoring of changes in ecDNA expression in the gastric mucosa may help predict the occurrence of gastric cancer and guide subsequent treatment. By collaborating with multiple endoscopic centers to conduct gastroscopy biopsies on patients with gastric precancerous lesions, we aim to further explore the role of ecDNA in the occurrence and development of gastric cancer through continuous follow-up.

Conditions

• Gastric Cancer
• Precancerous Lesion of Digestive Tract
• Extrachromosomal DNA

Interventions

PROCEDURE

gastroscopy

When performing gastroscopy, the endoscopist will perform a biopsy based on the condition of gastric mucosal lesions, with one specimen retained and the remaining specimens subjected to pathological examination

Sponsors & Collaborators

• Yuncheng Central Hospital

  collaborator OTHER

• Xi'an Honghui Hospital

  collaborator OTHER

• Xi'an No.9 Hospital

  collaborator UNKNOWN

• Xi'an No.3 Hospital

  collaborator OTHER_GOV

• Xijing 986 Hospital

  collaborator UNKNOWN

• Xijing Hospital

  lead OTHER

Principal Investigators

• Guo Xin · Xijing 986 Hospital

• Wang Tongfei · Xi'an No.3 Hospital

• Hao Junfeng · Xi'an No.9 Hospital

• Shi Yupeng · Xi'an Honghui Hospital

• Gao Xiaopeng · Yuncheng Central Hospital

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-08-10

Primary Completion

2028-07-20

Completion

2030-07-30

Countries

• China

Study Locations